Accommodative Responses to Chronic Irradiation: Effects of Dose, Dose Rate, and Pharmacological Response Modifiers
نویسندگان
چکیده
منابع مشابه
Differential Responses of Stress Genes to Low Dose-Rate ; Irradiation
In the past, most mechanistic studies of ionizing radiation response have employed very large doses, then extrapolated the results down to doses relevant to human exposure. It is becoming increasingly apparent, however, that this does not give an accurate or complete picture of the effects of most environmental exposures, which tend to be of low dose and protracted over time. We have initiated ...
متن کاملIncreased γ-H2A.X Intensity in Response to Chronic Medium-Dose-Rate γ-Ray Irradiation
BACKGROUND The molecular mechanisms of DNA repair following chronic medium-dose-rate (MDR) γ-ray-induced damage remain largely unknown. METHODOLOGY/PRINCIPAL FINDINGS We used a cell function imager to quantitatively measure the fluorescence intensity of γ-H2A.X foci in MDR (0.015 Gy/h and 0.06 Gy/h) or high-dose-rate (HDR) (54 Gy/h) γ-ray irradiated embryonic fibroblasts derived from DNA-depe...
متن کاملCharacterizing low dose and dose rate effects in rodent and human neural stem cells exposed to proton and gamma irradiation☆
Past work has shown that exposure to gamma rays and protons elicit a persistent oxidative stress in rodent and human neural stem cells (hNSCs). We have now adapted these studies to more realistic exposure scenarios in space, using lower doses and dose rates of these radiation modalities, to further elucidate the role of radiation-induced oxidative stress in these cells. Rodent neural stem and p...
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Introduction: Cancer is, in essence, a genetic disease and is the second leading cause of death globally. Fortunately, many common types of cancer are treatable if detected early and of course there are many medications and treatments available today. Among the new methods to treat cancer, radiotherapy seems to be hopeful in patients with malignancies. This work investigates th...
متن کاملDose-rate effects and dose and dose-rate effectiveness factor on frequencies of chromosome aberrations in splenic lymphocytes from mice continuously exposed to low-dose-rate gamma-radiation.
Dose-rate effects on chromosome aberrations in the low-dose-rate range have not been evaluated previously. The incidences of chromosome aberrations were analysed in splenic lymphocytes from female specific pathogen-free (SPF) C3H mice that were continuously irradiated with low- or medium-dose-rate (LDR, MDR) (137)Cs γ rays from 56 days of age to evaluate the dose-rate effects. The dose-response...
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ژورنال
عنوان ژورنال: Military Medicine
سال: 2002
ISSN: 0026-4075,1930-613X
DOI: 10.1093/milmed/167.suppl_1.82